Mouse Tumor Cells
Mouse tumor cell lines are one of the most commonly used experimental models in cancer biology, immuno-oncology, and preclinical drug development. These models, derived from spontaneous, chemically produced or genetically modified mouse tumors, are excellent tools to study tumor initiation, development, metastasis, immune modulation and treatment response.
We have a large variety of well-characterized mouse tumor cell models available for a number of different forms of cancer such as melanoma, breast cancer, lung cancer, colon cancer, lymphoma, leukaemia, liver cancer, and sarcoma. These cell lines are extensively used for syngeneic malignant studies, immunotherapy evaluation, molecular mechanism research, and anticancer drug screening applications.
Well-Established Immunocompetent-Compatible Research-Validated Supported
Key Features & Expertise
Our mouse tumor cell models support a wide range of oncology and immunology research applications
Broad Coverage of Mouse Cancer Models
- Includes commonly used models across solid tumors and hematologic malignancies
- Suitable for studies of tumor growth, invasion, metastasis, and angiogenesis
- Reflect diverse genetic and biological characteristics of murine cancers
Ideal for Immuno-Oncology & Syngeneic Studies
- Compatible with immunocompetent mouse models for syngeneic tumor experiments
- Widely used in immune checkpoint, CAR-T, and combination therapy research
- Support investigations into tumor microenvironment and immune response mechanisms
Reliable Quality & Experimental Consistency
- Quality controlled for reproducible research performance
- Mycoplasma-free and maintained using standardized culture procedures
- Cryopreserved stocks with stable supply and technical support available
FAQ
Why mouse tumor cell lines are so popular in cancer research?
Mouse tumor cell lines are very useful since they are compatible with syngeneic mice models and immunocompetent systems. This makes them very valuable for researching in vivo tumor-immune interactions, immunotherapy response and tumour development.
What is the benefit of employing mouse tumor cells in syngeneic models?
Unlike xenograft models that need immunodeficient mice, syngeneic models use mouse tumor cells transplanted in genetically matched immunocompetent mice. This enables researchers to study immune responses, checkpoint inhibitors and immunotherapies in a more physiologically appropriate environment.
What cancer types are commonly represented in mouse tumor cell collections?
Mouse tumor collections typically include models for melanoma, breast cancer, colorectal cancer, lung cancer, lymphoma, leukemia, liver cancer, pancreatic cancer, and sarcoma. These models support a broad range of oncology research applications.
Can we use mouse tumor cells for immunotherapy research?
Yes. Mouse tumor cell lines are widely employed in immuno-oncology studies, including checkpoint blocking, CAR-T therapy, tumor microenvironment analysis, cytokine research, and combination treatment evaluation.
Do mouse tumor cell lines maintain stable tumorigenicity over time?
Many mouse tumor cell lines retain stable tumorigenic potential when properly maintained. However, prolonged passaging may alter growth characteristics or immune-related phenotypes. Researchers are generally advised to use low-passage cells and establish working cell banks for consistency.
Are these cell lines suitable for both in vitro and in vivo studies?
Absolutely. Mouse tumor cells are commonly used in standard in vitro assays such as proliferation, migration, invasion, and drug sensitivity testing, as well as in vivo tumorigenicity and metastasis studies in syngeneic mouse models.
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Description: Established from a polyoma virus-induced osteogenic sarcoma in an A.SW mouse; cells were converted ...
Description: Murine radiation-induced acute myeloid leukemia (AML) cell line derived from splenocytes of the C3H ...
Description: Established from the splenocytes of a radiation-induced acute myeloid leukemia (AML) of the C3H ...
Description: Established from an adult female C3H/E1 mouse; non-tumorigenic urine bladder cell line immortalized ...
Description: Established from an adult female C3H/Law mouse; tumorigenic, invasive in vitro immortalized urine ...
Description: Established from an adult female C3H/Law mouse; non-tumorigenic in vitro immortalized urine bladder ...
Description: Established from bone marrow mast cells of a female BALB/c mouse in 1984
Description: Established from the bone marrow of a CBA/C57BL mouse in 1995
Description: Established from the ascites of a DBA/2 mouse with a lymphoid neoplasm induced by ...
Description: IL-3 dependent murine pro B cell line; the precise origin of the cell line is unclear; however, ...
Description: Established from Whitlock-Witte type long-term bone marrow culture of BC8 mice
Description: Spontaneous malignant transformation after homotransplanting MHEC5 NMRI mouse myocardial cells ...
Description: Established from the long-term bone marrow culture of B6D2F1 mice; cells are IL-3-dependent; their ...
Description: Established from the long-term bone marrow cultures of BDF1 mice; cells are mIL-3-dependent (FDCP ...
Description: Established by irradiation of the adherent cells in long-term bone marrow cultures derived from ...
Description: Established from the calvaria of an embryo/fetus C57BL/6 mouse. Cells have the capacity to ...
Description: Established from SV40-transformed BALB/c mouse embryo cells; cells are described as possessing SV40 ...
Description: Mouse erythroleukemia (MEL) cells were transformed by Friend leukemia virus strain 745A; the clone ...