Featured Products
- Adipose Tissue-Derived Stem Cells
- Human Neurons
- Mouse Probe
- Whole Chromosome Painting Probes
- Hepatic Cells
- Renal Cells
- In Vitro ADME Kits
- Tissue Microarray
- Tissue Blocks
- Tissue Sections
- FFPE Cell Pellet
- Probe
- Centromere Probes
- Telomere Probes
- Satellite Enumeration Probes
- Subtelomere Specific Probes
- Bacterial Probes
- ISH/FISH Probes
- Exosome Isolation Kit
- Human Adult Stem Cells
- Mouse Stem Cells
- iPSCs
- Mouse Embryonic Stem Cells
- iPSC Differentiation Kits
- Mesenchymal Stem Cells
- Immortalized Human Cells
- Immortalized Murine Cells
- Cell Immortalization Kit
- Adipose Cells
- Cardiac Cells
- Dermal Cells
- Epidermal Cells
- Peripheral Blood Mononuclear Cells
- Umbilical Cord Cells
- Monkey Primary Cells
- Mouse Primary Cells
- Breast Tumor Cells
- Colorectal Tumor Cells
- Esophageal Tumor Cells
- Lung Tumor Cells
- Leukemia/Lymphoma/Myeloma Cells
- Ovarian Tumor Cells
- Pancreatic Tumor Cells
- Mouse Tumor Cells
Hot Products
BCL2 FISH Probe
- Specification
- Q & A
- Customer Review
Cat.No.
FONC-125
Description
BCL2 FISH Probe is expertly designed to detect amplifications and deletions of the BCL2 gene, a crucial regulator of apoptosis. This probe is available with vibrant orange labeling for clear visualization, and customization options are offered to meet your specific research requirements.
BCL2 (B-cell lymphoma 2) is an essential gene that encodes a protein responsible for inhibiting programmed cell death, thereby promoting cell survival. Dysregulation of BCL2, often through chromosomal rearrangements, amplifications, or deletions, is commonly associated with various hematological malignancies, particularly follicular lymphoma and other B-cell lymphomas. The most notable alteration is the t(14;18) translocation, which leads to the overexpression of BCL2 and contributes to oncogenesis.
Clinical Relevance: Detecting BCL2 amplifications and deletions is vital for understanding the pathogenesis of B-cell malignancies. Identifying these genetic alterations can provide insights into disease prognosis and help guide treatment strategies, including the use of BCL2 inhibitors, which have shown promise in targeting BCL2-overexpressing tumors.
BCL2 (B-cell lymphoma 2) is an essential gene that encodes a protein responsible for inhibiting programmed cell death, thereby promoting cell survival. Dysregulation of BCL2, often through chromosomal rearrangements, amplifications, or deletions, is commonly associated with various hematological malignancies, particularly follicular lymphoma and other B-cell lymphomas. The most notable alteration is the t(14;18) translocation, which leads to the overexpression of BCL2 and contributes to oncogenesis.
Clinical Relevance: Detecting BCL2 amplifications and deletions is vital for understanding the pathogenesis of B-cell malignancies. Identifying these genetic alterations can provide insights into disease prognosis and help guide treatment strategies, including the use of BCL2 inhibitors, which have shown promise in targeting BCL2-overexpressing tumors.
Size
10 Tests; 20 Tests
Label
Orange/Green/Aqua
Specificity
Human
Locus
18q21.33
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no.
If your paper has been published, please click here
to submit the PubMed ID of your paper to get a coupon.
Ask a Question
Write your own review