The ETV6/RUNX1 Dual Fusion Probe is intended to detect the t(12;21)(p13;q22) translocation between the ETV6 gene and the RUNX1 gene using the fluorescence in situ hybridization (FISH) technique.
The t(12;21)(p13;q22) chromosomal translocation is the most common chromosomal rearrangement in childhood acute lymphocytic leukemia (ALL). Although not detectable by classical cytogenetics,1 the t(12;21) resulting in the fusion of the 5' section of the ETV6 (TEL) gene on chromosome 12p13 to almost the entire RUNX1 (AML1) gene located on chromosome 21q22 occurs in about 25% of childhood ALL.2 The Vysis ETV6/RUNX1 DF FISH Probe Kit uses a dual-color, dual-fusion probe design to detect the t(12;21) by fluorescence in situ hybridization.
For Research Use Only. Not for use in diagnostic procedures.
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