Uterine/Cervix Tumor Cells

Uterine and cervical tumors encompass a diverse range of malignancies, from HPV-associated cervical squamous cell carcinomas and hormone-responsive endometrial adenocarcinomas to rare Müllerian-origin tumors. These cancers exhibit distinct genetic alterations, differentiation states, and therapeutic sensitivities, posing significant challenges for both clinical management and in vitro research.

Our uterine/cervix tumor cell line collection offers a curated set of reliable in vitro models derived directly from human patient specimens. These models accurately reflect the biological complexity of the disease, including HPV integration, estrogen/progesterone receptor expression, and multi-drug resistance phenotypes, providing essential tools for investigating tumor progression, validating targeted therapies, and exploring mechanisms of treatment resistance.

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Key Features & Expertise

Our uterine/cervix tumor cell lines stand out for the following features

Diverse, Relevant, and Well-Characterized Models

Broad coverage of uterine and cervical cancers, including cervical squamous cell carcinoma, endometrial adenocarcinoma, and mixed Müllerian tumors
Representation of key biological features such as HPV16 integration and hormone receptor expression
Reflect the phenotypic and genetic heterogeneity of human uterine and cervical malignancies

Deep Characterization & Reliable Performance

Established from primary patient tumors (e.g., SKN, HeLa S3) and validated for growth characteristics
Documented phenotypes such as multi-drug resistance (e.g., MDR in KB-V1) and hormone responsiveness (e.g., HHHUA)
Consistent growth behavior suitable for reproducible in vitro studies and high-throughput screening

Quality You Can Trust

Rigorously tested to ensure authenticity and quality control
Cryopreserved and shipped under optimal conditions for experimental reliability
Stable supply with comprehensive technical support for your research needs

FAQ

What types of uterine and cervical tumors are represented in this collection?

This collection includes a variety of histological types such as cervical squamous cell carcinoma (e.g., SKN, TC-YIK), endometrial adenocarcinoma (e.g., HHHUA, EFE-184), and mixed Müllerian tumors (e.g., HTMMT). It covers both HPV-associated and hormone-responsive models.

Are there any HPV-positive cell lines available?

Yes, several cell lines in this collection are HPV-positive, such as TC-YIK (integrating HPV16) and HeLa S3 (originally derived from HPV18-positive cervical cancer). These models are valuable for studying viral oncogenesis and HPV-related therapies.

Which cell lines are suitable for hormone therapy research?

Cell lines expressing estrogen and progesterone receptors, such as HHHUA, are ideal for hormone therapy studies. These models allow researchers to investigate the effects of hormonal signaling on tumor growth and response to endocrine therapy.

Can these cell lines be used for drug resistance studies?

Absolutely. We offer multi-drug resistant variants like KB-V1 (derived from KB-3-1), which are specifically suited for studying chemotherapy resistance mechanisms and testing novel sensitizing agents.

How are these cell lines authenticated and maintained?

All cell lines undergo rigorous quality control, including morphological assessment and growth curve analysis. They are cryopreserved at early passages to ensure genetic stability and consistency across experiments.

What is the significance of the different HeLa derivatives?

The HeLa derivatives, such as HeLa S3, hela S3/DDP (cisplatin-resistant), and MR1-3 (MNNG-resistant), provide researchers with models that exhibit specific resistance phenotypes or altered growth behaviors, making them invaluable for comparative studies and therapeutic development.

Do you provide detailed characterization data for each cell line?

Yes, each cell line comes with detailed documentation, including origin, morphology, and key biological features. Additional characterization data, such as receptor status or resistance markers, are available upon inquiry to support your experimental design.

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