USA USA: 1-631-626-9181 Europe Europe: 44-207-097-1828  
Search

Tissue samples, tissue arrays, cells, microorganisms, probes and services for your research.

Web Search    Google
Featured Products
Browse Cells
Need help to Filer Cell Lines  by Type, Tissue and  Species?
Ordering Information

Payment methods we support:
✭ Invoice / Purchase Order
✭ Credit card


Human Hepatic Stellate Cells

  • Specification
  • Review & FAQ
  • Recommended Products
Cat.No.
CSC-C1496
Description
Hepatic stellate cells (HSteC) are intralobular connective tissue cells presenting myofibroblast-like or lipocyte phenotypes. They participate in the homeostasis of liver extracellular matrix, repair, regeneration, fibrosis and control retinol metabolism, storage and release. Following liver injury, HSteC transform into myofibroblast-like cells and are the major source of type I collagen in the fibrotic liver. Beyond these feature, HSteC have been implicated as regulators of hepatic microcirculation via cell contraction, and in disease states, in the pathogenesis of intrahepatic portal hypertension. Proliferation and migration of HSteC and expression of chemokines are involved in the pathogenesis of liver inflammation and fibrogenesis. HSteC possess voltage-activated calcium current, express the low affinity nerve growth factor receptor p75, and undergo apoptosis in response to nerve growth factor stimulation. Therefore, the new insight into the molecular regulation of HSteC activation will lead to therapeutic approaches in treatment of hepatic fibrosis in the future, and could lead to reduced morbidity and mortality in patients with chronic liver injury.

HHSteC are isolated from human liver. HHSteC are cryopreserved after purification and delivered frozen. HHSteC are characterized by immunofluorescent method with antibodies to desmin and α-actin. HHSteC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HHSteC are guaranteed to further expand for 15 population doublings in the conditions provided by Creative Bioarray.
Recommended Medium
It is recommended to use Stellate Cell Medium for the culturing of HHSteC in vitro.
Storage and Shipping
ship in dry ice; store in liquid nitrogen
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the Pub Med ID of your paper to get a coupon.
Q1:
We are interested in primary human hepatic stellate cells from healthy and fibrotic livers. Can you provide such cells?
A:

We can offer human hepatic stellate cells from healthy donors, but we do not routinely offer cells of any type from fibrotic livers. Enzymatic digestion of this tissue is almost always very poor, yielding poor quality cells.

Submit your review
Name *
Email *
User Comment *
Verification Code * Verification Code
Customer Support & Price Inquiry
Please input "bioarray" as verification code.
CONTACT US USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: 

Europe
Tel: 44-207-097-1828
Email: