Granzyme B is a serine protease stored in granules of activated cytotoxic T cells and NK cells. Upon target cell contact, granzyme B is directionally exocytosed and assisted by perforin, enters the target cell. With its unique substrate specificity (granzyme B cleaves after Asp), granzyme B processes and activates various pro-caspases thereby inducing apoptosis in the target cell.
Human GZMB expressed in E.coli
CAT# CSC-CTK0876-5 (5 μg); CAT# CSC-CTK0876-25 (25 μg)
16.12 units/mg protein
Liquid (0.2 mg/ml). In PBS containing 10% glycerol.
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