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Immortalized Human Hair Follicle Dermal Papilla Cells –SV40T/c-Myc
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Cat.No.
CSC-I9222L
Description
Human Hair Follicle Dermal Papilla cells are highly active mesenchymal cells isolated from the hair papilla embedded in extracellular matrix of scalp hair follicles. Dermal Papilla Cells play a significant role in controlling the hair growth cycle and production by involving in the epithelial-mesenchymal interaction of hair follicle cells. The Immortalized Human Dermal Papilla Cells (DPCs) express DPC specific markers smooth muscle alpha actin and alkaline phosphatase and retain the ability to secrete growth factors such as VEGF, PIGF, bFGF, IGFBP-6 and GM-CSF. DCP-conditioned media have also been shown to increase proliferation of HaCaT cellsin vitroand to accelerate hair growth in mice models. A list of up-regulated genes in the DPC can be found in the supporting document section below. The DPC serves as a useful tool for the study of hair growth regulation.
Species
Homo sapiens
Source
Hair follicles
Culture Properties
Adherent
Morphology
flat, polygonal
Immortalization Method
Serial passaging and transduction with recombinant lentiviruses carrying SV40 Large T antigen and c-Myc gene
Markers
smooth muscle alpha actin, alkaline phosphatase
Applications
For Research Use Only
Storage
Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture needed for experiments.
Note: Never can cells be kept at -20 °C.
Note: Never can cells be kept at -20 °C.
Shipping
Dry Ice.
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CSC-C4378X Primary Human Hair Follicle Dermal Papilla Cells
CIK-HT003 HT® Lenti-SV40T Immortalization Kit
CIK-HT003 HT® Lenti-SV40T Immortalization Kit
Quality Control
1) Western blot was used to identify SV40T and c-myc transgene expression.
2) Immunocytochemistry and western blot were performed to assess the expression of smooth muscle actin alpha and alkaline phosphatase. 3) Up-regulated genes in DPCs is analyzed by DAVID (the Database for Annotation, Visualization and Integrated Discovery) .
2) Immunocytochemistry and western blot were performed to assess the expression of smooth muscle actin alpha and alkaline phosphatase. 3) Up-regulated genes in DPCs is analyzed by DAVID (the Database for Annotation, Visualization and Integrated Discovery) .
BioSafety Level
II
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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