The adrenal gland plays an essential role in regulating homeostasis in the body through the secretion of corticosteroid and androgen hormones. The secreted steroids arise from three zones that form the adrenal gland: the zona glomerulosa, zona fasciculate, and zona reticularis. Microvascular endothelial cells line the blood vessels and contribute to many biological processes such as hemostasis, coagulation, trafficking of lymphocytes, and the inflammatory response. Microvascular endothelial cells (MEC) are of importance in the adrenal gland for their regulatory function on the secretion of adrenal hormones. Studies have shown that factors secreted from HAdMEC, such as endothelin-1, nitric oxide, adrenomedullin and PAMP affect aldosterone secretion. HAdMEC differ from MECs from different organs in function and phenotype. For example, compared to brain MEC and liver MEC, adrenal MEC are highly resistant to glucocorticoid-induced cytotoxicity showing that MECs are specialized to the tissues they belong to. HAdMEC from Bioarray Research Laboratories are isolated from human adrenal tissue. HAdMEC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10 5 cells in 1 ml volume. HAdMEC are characterized by immunofluorescent method with antibodies to vWF/Factor VIII and CED31 (P-CAM). HAdMEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HAdMEC are guaranteed to further culture for 15 population doublings in the conditions provided by Bioarray Research Laboratories
Storage and Shipping
Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture needed for experiments.
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Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders
Authors: Puccini J M, Marker D F, Fitzgerald T, et al.
The Journal of Neuroscience. 2015, 35(13): 5271-5283.