Established 1997 from the peripheral blood of a 45-year-old woman with aggressive natural killer cell (NK) leukemia; cells were described to display strong cytotoxic activity and to carry a point mutation in exon 7 of the TP53 (p53) gene
natural killer cell leukemia
round to polymorph cells growing singly and in clumps in suspension
STR DNA Profile
Human highly rearranged flat-moded hypertetraploid karyotype with 2.5% polyploidy; 84-96<4n>XXXX, +8, +8, +8, -9, t(5;6)(q21;q24)x2, der(7)t(4;7)(q31;q33)x2, der(7)dup(7)(q?31q?35)t(5;7)(p15;q35)x2, der(8)t(8;8)(p22;q24)inv(8)(q12q24)x2, der(9;10)(q10;q10
CD2 +, CD7 +, CD11a +, CD28 + , CD45 +, CD54 +, CD56 +, CD1 -, CD3 -, CD4 -, CD5 -, CD8 -, CD10 -, CD14 -, CD16 -, CD19 -, CD20 -, CD23 -, CD34 -, HLA-DR -
KRAS p.Gly12Ala (c.35G>C) TP53 p.Arg248Trp (c.742C>T)
a. Natural killer lymphoma related reserach
b. The study of enhanced cytotoxicity by NK cells
c. Cell-Based assay
d. In vivo efficacy study
Mycoplasma: Fluorescence (DAPI) test: negative; Mycoplasma specific PCR: negative; Selective biochemical test: negative
Viruses: ELISA: reverse transcriptase negative; PCR: EBV -, HBV -, HCV -, HHV-8 -, HIV-1 -, HIV-2 -, HTLV-I/II -, MLV -, SMRV -
Storage and Shipping
Ship in dry ice.
Store in liquid nitrogen.
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