The IGH/BCL2 Dual Color, Dual Fusion Translocation Probe is designed to detect the juxtaposition of immunoglobulin heavy chain (IGH) locus and BCL gene sequences. The translocation involving IGH at 14q32 and BCL2 at 18q21, t(14;18)(q32;q21) is common. Relocation of an IGH transcriptional enhancer next to the BCL2 gene as a result of the t(14;18) translocation is thought to cause constitutive over-expression of the anti-apoptotic BCL2 protein. The breakpoints at 14q32 occur at the IGH J segments and about 75% of the breaks at 18q21 occur in either the 2.8 kb major breakpoint region (MBR) 3' of BCL2 exon 3 or in the minor cluster region (MCR) located about 30 kb 3' to the MBR. The remaining BCL2 breakpoints are thought to lie between the MBR and MCR regions, or 5' of the BCL2 gene.
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