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BCR/ABL1/ASS1 Tri-Color Dual Fusion Probes
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Cat.No.
FHPC-021
Description
BCR/ABL1/ASS1 Tri-Color Probe is intended to detect the t(9;22)(q34;q11.2) reciprocal translocation involving the BCR and ABL1 gene regions using the fluorescence in situ hybridization (FISH) technique.
The t(9;22) translocation which fuses the BCR gene on chromosome 22q11.2 and the ABL1 gene on chromosome 9q34 is observed by cytogenetics in greater than 80% of those with chronic myelogenous leukemia (CML). In CML cases lacking a cytogenetically detectable translocation, the BCR/ABL1 fusion can still almost always be detected by FISH or other molecular techniques. BCR/ABL1 fusions also occur in a portion of acute lymphocytic leukemia cases and more rarely in acute myeloid leukemia. In about 15 to 20 percent of CML cases, the t(9;22) results in the loss of genetic material flanking the BCR and/or ABL1 breakpoints on the derivative 9 chromosome. This loss can prevent the production of the highly specific two-fusion signal patterns expected of dual fusion probes and balanced translocations.
The t(9;22) translocation which fuses the BCR gene on chromosome 22q11.2 and the ABL1 gene on chromosome 9q34 is observed by cytogenetics in greater than 80% of those with chronic myelogenous leukemia (CML). In CML cases lacking a cytogenetically detectable translocation, the BCR/ABL1 fusion can still almost always be detected by FISH or other molecular techniques. BCR/ABL1 fusions also occur in a portion of acute lymphocytic leukemia cases and more rarely in acute myeloid leukemia. In about 15 to 20 percent of CML cases, the t(9;22) results in the loss of genetic material flanking the BCR and/or ABL1 breakpoints on the derivative 9 chromosome. This loss can prevent the production of the highly specific two-fusion signal patterns expected of dual fusion probes and balanced translocations.
Size
10 Tests, 20 Tests
Label
Red/Green
Locus
9q34/22q11.2/9q34
Specificity
Human
Usage
For Research Use Only. Not for use in diagnostic procedures.Storage
Store at minus 20 centigrade
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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