BCR/ABL1/ASS1 Tri-Color Probe is intended to detect the t(9;22)(q34;q11.2) reciprocal translocation involving the BCR and ABL1 gene regions using the fluorescence in situ hybridization (FISH) technique.
The t(9;22) translocation which fuses the BCR gene on chromosome 22q11.2 and the ABL1 gene on chromosome 9q34 is observed by cytogenetics in greater than 80% of those with chronic myelogenous leukemia (CML). In CML cases lacking a cytogenetically detectable translocation, the BCR/ABL1 fusion can still almost always be detected by FISH or other molecular techniques. BCR/ABL1 fusions also occur in a portion of acute lymphocytic leukemia cases and more rarely in acute myeloid leukemia. In about 15 to 20 percent of CML cases, the t(9;22) results in the loss of genetic material flanking the BCR and/or ABL1 breakpoints on the derivative 9 chromosome. This loss can prevent the production of the highly specific two-fusion signal patterns expected of dual fusion probes and balanced translocations.
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