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Hot Products
BCR/ABL1/ASS1 Tri-Color Dual Fusion Probes
- Specification
- Q & A
- Customer Review
Cat.No.
FHPC-021
Description
BCR/ABL1/ASS1 Tri-Color Probe is intended to detect the t(9;22)(q34;q11.2) reciprocal translocation involving the BCR and ABL1 gene regions using the fluorescence in situ hybridization (FISH) technique.
The t(9;22) translocation which fuses the BCR gene on chromosome 22q11.2 and the ABL1 gene on chromosome 9q34 is observed by cytogenetics in greater than 80% of those with chronic myelogenous leukemia (CML). In CML cases lacking a cytogenetically detectable translocation, the BCR/ABL1 fusion can still almost always be detected by FISH or other molecular techniques. BCR/ABL1 fusions also occur in a portion of acute lymphocytic leukemia cases and more rarely in acute myeloid leukemia. In about 15 to 20 percent of CML cases, the t(9;22) results in the loss of genetic material flanking the BCR and/or ABL1 breakpoints on the derivative 9 chromosome. This loss can prevent the production of the highly specific two-fusion signal patterns expected of dual fusion probes and balanced translocations.
The t(9;22) translocation which fuses the BCR gene on chromosome 22q11.2 and the ABL1 gene on chromosome 9q34 is observed by cytogenetics in greater than 80% of those with chronic myelogenous leukemia (CML). In CML cases lacking a cytogenetically detectable translocation, the BCR/ABL1 fusion can still almost always be detected by FISH or other molecular techniques. BCR/ABL1 fusions also occur in a portion of acute lymphocytic leukemia cases and more rarely in acute myeloid leukemia. In about 15 to 20 percent of CML cases, the t(9;22) results in the loss of genetic material flanking the BCR and/or ABL1 breakpoints on the derivative 9 chromosome. This loss can prevent the production of the highly specific two-fusion signal patterns expected of dual fusion probes and balanced translocations.
Size
10 Tests, 20 Tests
Label
Red/Green
Specificity
Human
Locus
9q34/22q11.2/9q34
Usage

Storage
Store at minus 20 centigrade
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no.
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