The 4q12 Tri-Color Rearrangement FISH Probe is intended to detect rearrangements in chromosome 4q12 involving the FIP1L1-PDGFRA region, using FISH.
Chronic Eosinophilic Leukemia (CEL) is described by the World Health Organization (WHO) as a neoplasm in which clonal proliferation of eosinophil precursors results in prolonged eosinophilia. The chromosomal anomaly, del(4)(q12q12), results in a fusion of FIP1L1 and PDGFRA and is found in 40-60% of CEL syndromes. The Vysis LSI 4q12 Tri-Color Rearrangement Probe has been used to detect an approximately 800 kb deletion containing LNX and CHIC2 and subsequent fusion of FIP1L1 and PDGFRA. The current WHO classification system places myeloproliferative neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1 into their own detective category, while CEL lacking aberrations of these and several other genes falls into the CEL, not otherwise specified
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