SuperQuick® Cytochrome P450 2C9 (CYP2C9) Inhibitor Screening Kit

DMK-YS006

CYP2C9 is predominantly expressed in the liver and catalyzes the oxidation of weakly acidic or hydrophobic small molecules containing aromatic molecules and at least one hydrogen bond donor. Isoforms of the CYP2C subfamily are involved in the metabolism of nearly 20% of commonly used small molecule drugs.The human CYP2C9 gene has a high degree of single nucleotide polymorphisms (SNPs) that have been implicated in clinical drug-drug interactions. In addition, for drugs whose pharmacological activity requires metabolism from the prodrug form, CYP2C9 inhibition or allelic deficiency can lead to reduced drug efficacy.Creative Bioarray's CYP2C9 Inhibitor Screening Kit provides rapid screening of compound-CYP2C9 interactions in a high-throughput fluorescent assay.

Perform rapid, high-throughput screening and characterization of compound interactions with CYP2C9.
Predict the adverse drug interaction potential and bioavailability of compounds metabolized by CYP2C9.

CYP2C9Assay Buffer;
7-HFC Standard;
CYP2C9 Inhibitor (Tienilic Acid);
NADPH Generating System(100X);
β-NADP+Stock (100X);
CYP2C9 Substrate;
Recombinant Human CYP2C9.

100 assys

Chemical compounds

Strore at -20℃.

Gel Pack

Simple and ready to use;
Rapid and high-throughput;
Hight sensitive.

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