SuperQuick® Cytochrome P450 1A2 (CYP1A2) Inhibitor Screening Kit

DMK-YS010

CYP1A2 catalyzes the oxidation of polyaromatic hydrocarbons and heterocyclic compounds and is found mostly in the liver, nasal mucosal tissues, and the intestine. About 10% of routinely used small molecule medicines have CYP1A2 implicated in their metabolism. Clinical drug-drug interactions involving frequently used medications, such as caffeine, theophylline, and the antipsychotic clozapine, have been linked to polymorphisms in the human CYP1A2 gene. Environmental carcinogens included in cigarette smoke and combustion exhaust are also activated metabolically by isoforms of the CYP1A2 subfamily.Creative Bioarray's CYP1A2 Inhibitor Screening Kit provides rapid screening of compound-CYP1A2 interactions in a high-throughput fluorescent assay.

Perform rapid, high-throughput screening and characterization of compound interactions with CYP1A2.
Predict the adverse drug interaction potential and bioavailability of compounds metabolized by CYP1A2.

CYP1A2Assay Buffer;
3-CHC Standard ;
CYP1A2 Inhibitor (α-naphthoflavone);
NADPH Generating System(100X);
β-NADP+Stock (100X);
CYP1A2 Substrate;
Recombinant Human CYP1A2.

100 assys

Chemical compounds

Strore at -20℃.

Gel Pack

Simple and ready to use;
Rapid and high-throughput;
Hight sensitive.

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.