The leukemias are often characterized by multiple genetic aberrations distributed across the genome. In some cases, the same genetic aberrations are shared by different types of leukemia. Trisomy 12 and deletions of chromosomes 13q (primarily the 13q14 region), 17p13.1, and 11q22.32-4, for example, have all been observed in several types of leukemia. Probe vial 1 contains LSI p53 in SpectrumOrange and LSI ATM in SpectrumGreen. Probe vial 2 contains D13S319 in Red, LSI 13q34 in SpectrumAqua, and CEP 12 in Green.
The ATM probe is a 500 kb unique sequence probe that hybridizes to the 11q22.3 region of chromosome 11. This probe spans the entire 184 kb Ataxia telangiectasia mutated (ATM) gene and several others.
For Research Use Only. Not for use in diagnostic procedures.
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