EGFR abnormalities including increased copy number and amplification have been correlated with the development of many solid tumors, including non-small cell lung cancer (NSCLC) which is the leading cause of cancer death worldwide .
NSCLC has a 5-year survival rate of approximately 15%.Inhibition of EGFR by agents that block its tyrosine kinase domain has been demonstrated to reduce proliferation of lung cancer cells, resulting in suppression of tumor growth.
7p12/7p11.1-q11.1 Alpha Satelite DNA
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