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Immortalized Mouse Urogenital Sinus Mesenchymal Cells (UGSM-2)
Cat.No.: CSC-I9252L
Species: Mus musculus
Source: Prostate
Morphology: Spindle-shape fibroblast-like
Culture Properties: Adherent
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Co-culture of UGSM-2 cells with human prostate epithelium cells BPH-1, or co-graftingin vivoresults in organized clusters of BPH-1 cells surrounded by a mantle of the UGSM-2 cells. The cells are responsive to Sonic hedgehog (SHH), an important signaling factor in prostate development, and mimic the transcriptional response of the intact UGS mesenchyme. This cell line is a useful model for studying the prostate stroma-epithelium signalling way, which plays an important role in prostate development and cancer progression.
Note: Never can cells be kept at -20 °C.
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