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Immortalized Mouse Calvarial Mesenchymal Progenitor Cells (iCALs)
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Cat.No.
CSC-I9262L
Description
The bone morphogenetic proteins (BMPs) produced by calvarial cells are crucial in osteoblastic differentiation and bone regeneration, however the limited lifespan of primary cells diminishes their usefulness in translational research. The Immortalized Mouse Calvarial Mesenchymal Progenitor Cell Line (iCALs) retains the morphology and progenitor cell profile phenotype of primary calvarial cells in addition to preserving BMP-2 –induced osteogenic differentiation. These cells are effective for research examining potential novel small molecule therapeutic agents, cranial reconstruction, alleviation of congenital defects, or the intracellular processes responsible for intramembranous bone formation.
Species
Mus musculus
Source
Calvariae
Culture Properties
Adherent
Morphology
Fibroblast-like
Immortalization Method
Serial passaging and infection with retrovirus carrying loxP-flanked SV40 large T antigen
Markers
CD166, CD73, CD44, CD105
Applications
For Research Use Only
Storage
Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture needed for experiments.
Note: Never can cells be kept at -20 °C.
Note: Never can cells be kept at -20 °C.
Shipping
Dry Ice.
Recommended Products
CIK-HT003 HT® Lenti-SV40T Immortalization Kit
Quality Control
Immunofluorescent staining for mesenchymal stem cell markers
BioSafety Level
II
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
CSC-I9001L
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