SuperQuick® Cytochrome P450 3A4 (CYP3A4) Inhibitor Screening Kit

DMK-YS002

CYP3A4 is abundantly expressed in the liver and intestine, where it catalyzes the oxidation of a variety of structurally different ligands. Of all small molecule drugs commonly used in humans, more than half are metabolized by CYP3A4, and inhibition of CYP3A4-mediated metabolism is a common cause of drug/drug and drug/food interactions and toxicity.In addition, for the pharmacological activity of a drug to be metabolized from the prodrug form, inhibition of CYP3A4 can lead to decreased drug efficacy.Creative Bioarray's CYP3A4 Inhibitor Screening Kit allows rapid screening of compound-CYP3A4 interactions in a high-throughput fluorescent assay.

Perform rapid, high-throughput screening and characterization of compound interactions with CYP3A4.
Predict the adverse drug interaction potential and bioavailability of compounds metabolized by CYP3A4.

CYP3A4 Assay Buffer
Resorufin Standard (5 mM in DMSO);
CYP3A4 Inhibitor (Ketoconazole);
NADPH Generating System(100X);
β-NADP+Stock (100X);
CYP3A4 Substrate;
Recombinant Human CYP3A4.

200 assys

Chemical compounds

Strore at -20℃.

Gel Pack

Simple and ready to use;
Rapid and high-throughput;
Hight sensitive.

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