Esophageal FISH Probe Kit is designed to detect copy number of ERBB2 (17q12), p16 (9p21), MYC (8q24) and ZNF217 (20q13.2) loci via fluorescence in situ hybridization (FISH) in cytology (esophageal brushing) specimens and in formalin-fixed, paraffin-embedded esophageal tissue specimens.
Esophageal FISH Probe Kit utilizes four Locus-Specific Identifier (LSI) probes to identify copy number changes of the ERBB2 (17q12), p16 (9p21), MYC (8q24), and ZNF217 (20q13.2) chromosomal loci, using a multi-color FISH test. These four loci have been shown to be associated with dysplasia and esophageal adenocarcinoma (EAC) in Barrett's esophagus (BE). BE is believed to increase the risk of EAC. The rise in incidence of this pre-malignant condition has been linked to a rapid increase in the incidence of EAC in Western European countries, Canada, and the US. The incidence of EAC has been growing at a rate exceeding that of any other cancer, 4% to 10% annually over the past two decades, while the 5-year survival rate remains less than 10%.
For Research Use Only. Not for use in diagnostic procedures.
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