Diffuse gliomas of the central nervous system are classified based on their histological appearance as astrocytomas, oligodendrogliomas and mixed oligoastrocytomas. Fluorescence in situ hybridization using 1p36 and 19q13 LSI FISH probes showed that the oligodendroglial phenotype was also associated with the 1p deletion and that allelic loss of 1p was a powerful predictor of chemotherapeutic response. Combined 1p36-19q13 deletions were highly associated with classic oligodendroglioma histology and a longer survival rate.
The 1p36/1q25 and 19q13/19p13 probes performed successfully in several studies to detect losses in 1p36 and 19q13.6-7 FISH testing using this probe set in an analysis of 81 histologically confirmed samples (glial tumors, WHO grade I-IV) supported previous study findings that loss of 1p36 and 19q13 is highly correlated with tumors with oligodendroglial component.6 Wharton et al. detected 1p and 19q deletions in the majority of samples graded as oligodendrogliomas, WHO grade II and III.
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