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Scopolamine induced amnesia is one of the most common AD-related model targeting cholinergic neurons, which is often used to explore the role of cholinergic in dementia and to screen drugs for AD. In addition, there are other substances that cause similar pathological phenotypes of AD, including okadaic acid for tau phosphorylation, endotoxins for brain inflammation, sodium azide for mitochondrial dysfunction and heavy metal for inducing reactive oxygen species.
Figure. 1. Intracerebral injection in mice
Induced damage models include but not limited to:
With 10 years of hard working and continuous development, as a senior leader specialize in AD research with enormous industrial experience, Creative Bioarray is exceptionally positioned to be your partner. We will make our best efforts to meet your unique requires by providing individually customized service.
Figure. 2. Effect of statin treatment on hippocampal damage induced by KA (kainate)
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Alzheimer's Disease Modeling and Assays:
In Vivo Model Service:
Induced Damage Model: