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Scopolamine is a non-selective muscarinic receptor antagonist that impairs spatial learning and memory abilities by blocking cholinergic signaling as well as some possible indirect effects. It is one of the commonly used drugs in chemical-induced Alzheimer's disease model. For example, rat dementia is usually induced by intraperitoneal injection for two weeks (1mg/kg).
Figure. 1. Pharmacological changes of scopolamine-induced AD model
Creative Bioarray has many years of experience in the field of Alzheimer's disease and provides pharmacodynamic services for customers to help them assess the efficacy of compounds and study the associated pathological mechanisms of Alzheimer's disease through scopolamine induced model.
With years of experience in AD research field, Creative Bioarray understands how to help design the studies to obtain rapid and clear answers to meet our customers’ need. Our in vivo animal models are capable of providing a rapid screening of the neuroprotective potential agents for the treatment of AD.
Figure. 2. 7,8-Dihydroxyflflavone (7,8-DHF) attenuated scopolamine-induced learning and memory defificits. (A) Latency of the rats to find the platform during the training section. Latency (B) and crossing time (C) of the rats on the 7th day. (D) Swimming speed of all groups. (*) p < 0.05, (**) p < 0.01 versus the control (Con) group, (#) p < 0.05, (##) p < 0.01versus the scopolamine (Sco) group. S + D, Sco + 7.8-DHF.
Figure. 3. 7,8-Dihydroxyflflavone (7,8-DHF) reversed scopolamine (Sco)-induced synaptic impairments. (A) Normalized population spike (PS) amplitude. (B) Normalized excitatory postsynaptic potential (EPSP) slope. S + D, Sco + 7.8-DHF; Con, control; HFS, high-frequency stimulation.
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