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Danio rerio (zebrafish) have been used as a powerful tool in neuroscience research and drug screening due to their simple nervous system, small body size, feasible experimental manipulations as well as quantifiable behaviors. Importantly, many AD associated genes in Danio rerio are evolutionarily conservative compare to ours, including co-orthologues to PSEN1, PSEN2 and APP (Appa and Appb). GSK3β plays a crucial role in energy metabolism, apoptosis and cell motility and is abnormally up-regulated in AD pathogenesis. Inhibition of GSK3β activity has been viewed as a potential therapeutic approach for AD.
Creative Bioarray specializes in providing customized pharmacodynamic research services to help customers assess the efficacy of drug candidates and study the associated pathological mechanisms through Danio Rerio models.
Figure. 1. Danio rerio
Creative Bioarray provides you with Danio Rerio models including but not limited to:
Creative Bioarray has years of experience in establishing Danio Rerio models. We also provide varieties of services including behavioral testing and molecular marker evaluation to meet your specific needs. We are confident to help you to overcome possible upcoming challenges in your research. With our help, we wish to facilitate your study with high efficiency.
Fig. 2. Agathisflavone (FAB, 1 µg/l, 3µg/l and 5 µg/l) improved locomotor pattern and decreased anxiety in the NTT test. (A) Representative locomotion tracking of the control, Scopolamine (100 µM), FAB (1 µg/l, 3µg/l and 5 µg/l) and IMP (20 mg/l) treated groups. (B) Represent total distance travelled by zebrafish in tank in different groups. (C) Represent the time spent by zebrafish in the top zone of the tank in different groups. (D) Represent the time spent by zebrafish in the bottom zone of the tank in different groups. Values are means ± S.E.M. (n = 20). For Turkey’s post hoc analyses: #Sco vs. FAB (3 µg/l): p<0.01 and ##Sco vs. FAB (5 µg/l): p<0.001.
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