Aging Models
Aging-induced memory loss is characterized by behavioral deficit and cognitive function impairments, which often occurs along with the aging process. Therefore, aged animals may be used as a natural aging model to study the molecular mechanisms of AD as well as preclinical candidate drug screening. A variety of animals are found to spontaneously develop AD neuropathological hallmarks similar to those observed in humans.
Figure. 1. 18-month-old mouse
Aging models with different advantages include but not limited to:
- Natural aging model
- Rapid aging model
- D-gal induced model
Our capabilities
- Behavioral and cognitive function tests
- Histopathology assays
- Mechanism/ signaling pathway studies
- Biomarkers discovery
Assays available
- Learning and memory deficits tests
- Synaptic impairment
- Oxidative stress
- Neuroinflammation
- Phosphorylated tau
- Glycogen synthase kinase-3 beta (GSK3β)
- Neurofilament Light Chain levels
- Neuronal loss
- β-AP level
- Plaque load
- β-sheet load
- pE(3)-Aβ load
- Enzyme activity related to cholinergic system
- NMDA receptor function and excitotoxicity
- Mitochondrial dysfunction
- Brain slice staining and synaptic electrophysiology
- Blood brain barrier homeostasis
- Cerebral vascular angiopathy (CAA)
With 10 years of hard working and continuous development, as a senior leader specialize in AD research with enormous industrial experience, Creative Bioarray is exceptionally positioned to be your partner. We will make our best efforts to meet your unique requires by providing individually customized service.
Study examples
Figure. 2. β-asarone attenuated neuronophagia and lipofuscin of hippocampus in SAMP8 mice.
Quotation and ordering
If you have any special needs or questions regarding our services, please feel free to contact us. We look forward to cooperating with you in the future.
References
- Takeda T et al. A new murine model of accelerated senescence. Mechanisms of Ageing & Development. 1981; 17: 183-94.
- Chen Y et al. β-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in a senescence-accelerated prone 8 mice. Brain Research. 2014; 1552: 41-54.
