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Creative Bioarray is offering cell immortalization service. With years of experience in cell immortalization, we have been able to successfully immortalize cells from human, mouse, bovine and dog, using different immortalizing agents or genes. Our custom immortalization service can significantly extend replicative capacity of your target cells, which saves your time and money over trying by yourself.
Primary cells normally have a limited life span and after having undergone a certain number of population doublings stop dividing, this is known as senescence. Re-establishing fresh cultures from explanted tissue is a tedious process. However, using immortalized cells can solve this problem. Immortalized cells have extended replicative capacity and offer the possibility of an inexhaustible supply of cells throughout your research project.
There are several methods for generating immortalized cell lines. One method is introduction of a viral gene that partially deregulates the cell cycle, such as EBV, SV40 T antigens and HPV-16 E6/7 gene. Artificial expression of key proteins required for immortality is another approach to induce immortalization, for example telomerase which prevents degradation of chromosome ends during DNA replication in eukaryotes. Another method is inactivation of tumor suppression genes, such as p53, Rb and others. Creative Bioarray over the years has developed a robust protocols making cell immortalization process simpler and easier than ever before.
Creative Bioarray offers cell immortalization service for your scientific research as follows:
If you have any special needs in constructing an immortalized cell line from primary cells, please contact us at firstname.lastname@example.org or 1-631-626-9181 for this special service. Let us know what you need and we will accommodate you. We look forward to working with you in the future.