Morris Water Maze Test
The Morris water maze is a classic behavioral test of assessing the hippocampal-dependent learning process and spatial memory for rodents. Morris water maze generally includes circular water pool, shade, automatic video recording system and software analysis system. Rodents subjected to Morris water maze have to remember spatial cues to locate the escape platform hidden underwater. Learning and memory function is evaluated by the latency to identify the escape platform and the swimming distance to find the hidden platform. Creative Bioarray offers Morris water maze to evaluate the effects of preclinical drug candidates on cognitive functions of rodent models.
Figure. 1. Morris water maze
We have extensive experience in Morris water maze test to assess learning and memory functions of rodent models, Our service could bolster your research in screening of compounds aimed to treat Alzheimer's disease. Our experts make every effort to design optimized and specific projects to serve our clients.
Study examples
Fig. 2. Effects of simvastatin (Sim) administration on learning and memory function of rats in Morris water maze test (n = 8 in each group). During place navigation stages on days 17-20 following STZ injection, time taken for the rats to find the platform (a) and total distance traveled (b) in each trial were measured. Percentage of time (c) and distance (d) spent in the goal quadrant (platform area) during probe test is shown in the Figure. There were significant differences between STZ + Sim and STZ + DMSO in distance moved and escape latency during days three and four of place navigation stages. Swimming speed did not change significantly in different groups during four days of place navigation (e). Values are expressed as mean ± SEM. *p ˂ 0.05 and ***p ˂ 0.001 compared with Saline + DMSO group; #p < 0.05 compared with STZ + DMSO group; †p < 0.05 and †††p < 0.001 compared with STZ + Sim group.
Quotation and ordering
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Reference
- Adeli S et al. Simvastatin Attenuates Hippocampal MMP-9 Expression in the Streptozotocin-Induced Cognitive Impairment. Iran Biomed J. 2019 Jul;23(4):262-71.
