Weight-Drop Model
If you're looking to gain a better understanding of the pathophysiology of traumatic brain injury (TBI) or develop a therapy for TBI, Creative Bioarray has the solution for you. We have established a highly effective weight drop model that can help you obtain accurate and reliable results about your test compounds. Our weight drop model for TBI is designed with precision and care to give you detailed insights into the mechanism of TBI and assist you in your research endeavors. With our cutting-edge technology and expertise, you can rest assured that you are in good hands.
The weight drop model has been an indispensable tool in neuroscience research for several decades. This model has significantly contributed to our understanding of the pathophysiology of TBI. In the weight drop model, the skull is exposed to a free falling, guided weight. Injury severity in this model can be altered by adjusting the mass of the weight and the height from which it falls.
Fig. 1 Weight drop model of TBI
Our Weight Drop Model
- Available Animal
Rat - Group Setting
- Sham group
- Model group
- Three dose groups of the test compound
- Endpoints
- Body weight
- Behavioral tests: Rotarod test, Morris water maze, etc.
- Histology analysis: H&E staining
- Clinical score: mNSS score
- Brain water content
- Other customized endpoints: available upon request
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Example Data
Fig. 2 Effect of IH100 and IH120 TBI on Barnes maze (BM) performance.
Additionally, we provide other TBI rodent models that you may be interested in:
Quotation and Ordering
Creative Bioarray, as a leading provider of disease models, offers a range of services to our clients, including assistance with designing studies that are tailored to their specific goals. By working with us, you can be sure that your studies will be designed to maximize the amount of data that can be obtained from a single animal. So, whether you are looking to conduct basic research or develop new therapies, we are here to help. If you are interested in our services, please feel free to contact us at any time or submit an inquiry to us directly. We look forward to cooperating with you.
References
- Xiong, Y., et al. Animal models of traumatic brain injury. Nat Rev Neurosci. 2013; 14: 128–142.
- Chakraborty, N., et al. TBI weight-drop model with variable impact heights differentially perturbs hippocampus-cerebellum specific transcriptomic profile. Exp Neurol. 2021, 335:113516.
