Controlled Cortical Impact Injury (CCI) Model
If you are looking for reliable and accurate data on traumatic brain injury (TBI) about your compounds, you may be interested to know that Creative Bioarray has established and validated a model of TBI using the Controlled Cortical Impact Injury (CCI) Model. This widely recognized model is the most commonly used approach to simulate TBI in preclinical research. At Creative Bioarray, we conduct contract research using this model to help you get the most out of your studies. Our team of experts is dedicated to providing you with high-quality data so that you can advance your research with confidence.
TBI is a significant public health concern that requires further research efforts. To better understand TBI and concussion, animal models have been utilized, with CCI being a well-characterized and widely used experimental model for three decades. One of the key strengths of the CCI model is its scalability to several laboratory animals, enabling researchers to produce graded TBI ranging from mild to severe. This model has been employed in various studies, including the investigation of open and closed-head TBI, repeated injuries, and the long-term deficits associated with TBI and concussion.
Fig. 1 Controlled cortical impact (CCI) injury model in mice
Our Controlled Cortical Impact Injury (CCI) Model
- Modeling Method
At Creative Bioarray, the CCI model is established by a precision percussion device. - Available Animal
- Rat
- Mouse
- Group Setting
- Sham group
- Model group
- Three dose groups of the test compound
- Endpoints
- Body weight
- Histology analysis: H&E staining,
- Behavioral tests: Rotarod test, Morris water maze test, etc.
- Clinical score: Glasgow coma scale (GCS) score
- Brain water content
- qPCR and Western Blot
- Other customized endpoints: available upon request
……
Example Data
Fig. 2 JC124 treatment reduced the cortical tissue damage following CCI.
Fig. 3 The mNSS score of implanted TBI mice in each group.
Additionally, we provide other TBI rodent models that you may be interested in:
Quotation and Ordering
With years of scientific expertise and state-of-the-art facilities, Creative Bioarray provides our clients with exceptional services. Our team of experts is always ready to assist clients in designing study plans and protocols tailored to their specific needs. If you are interested in our service, please do not hesitate to contact us or submit an inquiry to us directly. We look forward to cooperating with you.
References
- Guo, D., et al. Rapamycin attenuates the development of posttraumatic epilepsy in a mouse model of traumatic brain injury. PloS one, 2013, 8(5): e64078.
- Kuwar, R., Rolfe, A., et al. A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury. J Neuroinflammation, 2019, 11;16(1):81.
- Wang, L., Zhang, D., et al. Injectable hyaluronic acid hydrogel loaded with BMSC and NGF for traumatic brain injury treatment. Materials Today Bio, 2022, 13: 100201.
- Lu, D., Wang, Y., et al. Armcx1 attenuates secondary brain injury in an experimental traumatic brain injury model in male mice by alleviating mitochondrial dysfunction and neuronal cell death. Neurobiology of Disease, 2023, 184: 106228.
