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Bronchial asthma is a chronic disorder accompanied by phenotypic transitions of bronchial epithelial cells, smooth muscle cells, and fibroblasts. Human bronchial fibroblasts (HBFs) derived from patients with diagnosed asthma display predestination towards TGF-β-induced phenotypic switches. Since the interference between TGF-β and GSK-3β signaling contributes to pathophysiology of chronic lung diseases, we investigated the effect of lithium, a nonspecific GSK-3β inhibitor, on TGF-β(1)-induced fibroblast to myofibroblast transition (FMT) in HBF and found that the inhibition of GSK-3β attenuates TGF-β(1)-induced FMT in HBF populations derived from asthmatic but not healthy donors. Read more >
Homeobox (Hox) genes code for transcriptional factors and are expressed during many developmental and differentiative processes. In this study, we describe the induction of Hox 1.3 expression by retinoic acid (RA) in human bronchial fibroblasts (HBF) derived from explants of bronchial tissue. Using Northern blot analysis, we show that RA induces Hox 1. Read more >
Human airway trypsin-like protease (HAT) was isolated from airway secretions and localized to bronchial epithelial cells by immunohistochemistry. In the present study, we examined whether HAT could stimulate DNA synthesis and proliferation of primary human bronchial fibroblasts (HBF). HAT significantly stimulated the proliferation of HBF by 20-55%, a level similar to that of the mitogenic activity of lung mast cell tryptase (MCT). Read more >
Retinoids are important regulators of the growth and differentiation of tracheobronchial epithelial cells. To determine the mechanism of action of retinoids in these cells, we began to examine the expression of nuclear retinoic acid receptors (RARs) in normal human and rabbit tracheobronchial epithelial (HBE and RbTE, respectively) cells and in several lung carcinoma cell lines. Read more >
The role of airway wall remodelling in bronchial asthma is well established. Myofibroblasts, the cells displaying features intermediate between fibroblasts and smooth muscle cells, are involved in this process but the mechanism of myofibroblasts activation in the onset of the disease remains obscure. Read more >
|Cat#||Product Name||Description||Recommended Medium||Price|
|CSC-C4021X||Human Tracheal Smooth Muscle Cells (HTSMC)||Smooth muscle tissue is found in the tunica m...||-----||INQUIRY|
|CSC-C4022X||Human Tracheal Epithelial Cells (HTEpC)||The epithelium is the interface between the b...||-----||INQUIRY|
|CSC-C4074X||Lobar Bronchial Epithelial Cells||Special edition cells are isolated from the t...||-----||INQUIRY|
|CSC-C4125X||Normal Human Bronchial/Tracheal Epithelial Cells||Creative Bioarray's normal Human Bronchial/Tr...||-----||INQUIRY|
|CSC-8244W||Human Tracheal Fibroblasts||Human Primary Tracheal Fibroblasts are isolat...||-----||INQUIRY|
|CSC-C9087W||BEAS-2B||Epithelial cells were isolated from normal hu...||SuperCult® BEAS-2B medium||INQUIRY|
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