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CAL-27

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  • Specification
  • Questions & FAQ
  • Recommended Products
  • Cat.No.
  • CSC-C0478
  • Description
  • The CAL-27 cells are established from the poorly differentiated squamous cell carcinoma of the tongue removed from a 56-year-old man before treatment in 1982. CAL 27 cells are epithelial, polygonal with a highly granular cytoplasm. Immunocytochemical studies show strong positive staining with anti keratin antibodies. The cells do not grow well in semi-solid medium. Marked inhibition of thymidine incorporation was observed in the presence of VP16 (etoposide), CCNU (1-[2-chloroethyl]-3-cyclohexyl-1-nitrosourea), VM26 (teniposide), ADM (adriamycin), CPA (cyclophosphamide), and MTX (methotrexate). CAL 27 cells were resistant to treatment with VDS (vindesine sulfate), CDP (cis-platinum) or ACTD (actinomycin D).
  • Organism
  • Homo sapiens, human
  • Morphology
  • Epithelial
  • STR DNA Profile
  • Amelogenin: X
    CSF1PO: 10,12
    D13S317: 10,11
    D16S539: 11,12
    D18S51: 13
    D21S11: 28,29
    D3S1358: 16
    D5S818: 11,12
    D7S820: 10
    D8S1179: 13,15
    FGA: 25
    Penta D: 9,10
    Penta E: 7
    TH01: 6,9,3
    TPOX: 8
    vWA: 14,17
  • Culture Properties
  • monolayer
  • Karyotype
  • Human flat-moded hypodiploid karyotype with 3% polyploidy - 41(38-45)<2n>X, -Y, -4, +7, -10, -11, -18, -20, -21, -22, +2-3mar, add(3)(q21), i(3q), i(7p), del(8)(p21), i(9q), add(13)(p11), add(14)(p11) - sideline with additional der(3) and der(7) - resembl
  • Source
  • Tongue
  • Quality Control
  • Mycoplasma: negative in DAPI, microbiological culture, RNA hybridization, PCR assays
    Immunology: cytokeratin +, cytokeratin-7 -, cytokeratin-8 +, cytokeratin-17 +, cytokeratin-18 +, cytokeratin-19 -, desmin -, endothel -, EpCAM +, GFAP -, neurofilament -
  • Storage and Shipping
  • Frozen with 70% medium, 20% FBS, 10% DMSO at about 1 x 10^6 cells/ampoule; ship in dry ice; store in liquid nitrogen
  • Tissue
  • Tongue
  • Application
  • These cells have been used in studies of anti-tumour agents.

  • Disease
  • Squamous cell carcinoma

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    • USA
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      Tel: 1-631-626-9181
      Fax: 1-631-614-7828
      Email: info@creative-bioarray.com
      Europe
      Tel: 44-207-097-1828
      Email: info@creative-bioarray.com
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Contact Us
USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-bioarray.com

Europe
Tel: 44-207-097-1828
Email: info@creative-bioarray.com