Method for the Prognosis and Treatment of Renal Cell Carcinoma Metastasis: U.S. Patent Application 14/776,390[P].

Method for the Prognosis and Treatment of Renal Cell Carcinoma Metastasis: U.S. Patent Application 14/776,390[P]. Authors: Gomis R, Lacey D L.
PCT/IB2014/001715

Abstract

The present invention relates to a method for the prognosis of bone metastasis in renal cell carcinoma which comprises determining if the c-MAF gene is amplified in a primary tumor sample. Likewise, the invention also relates to a method fordetermining the tendency to develop bone metastasis with respect to metastasisin other organs, which comprise determining the c-MAF gene expression level, amplification or translocation. The invention also relates to a method for predicting early bone metastasis in a subject suffering renal cell carcinoma. The invention also relates to a c-MAF inhibitor as therapeutic agent for use in the treatment ofrenal cell carcinoma metastasis. The invention relates to kits for predicting bone metastasis and predicting the clinical outcome of a subject suffering from bone metastasis. Finally, the invention relates to a method for typing of a subject suffering renal cell carcinoma and for classifying a subject from renal cell carcinoma into a cohort.