FMS-like Tyrosine Kinase 3 is a cytokine that regulates proliferation and differentiation of various blood cell progenitors. It is used in the cell and gene therapy space for the ex vivo expansion of HSCs that are used for transplantation.
TQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTA
Approximately 17.6 kDa, a single non-glycosylated polypeptide chain containing 155 amino acids
5μg, 100μg, 500μg, 1000μg
Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human AML5 cells is less than 1.0 ng/ml, corresponding to a specific activity of > 1.0 × 106 IU/mg.
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
This GMP product can be for research use or further manufacturing use.(NOT FOR HUMAN USE)
Store lyophilized cytokine at -20°C to -80°C.
Avoid repeated freeze/thaw cycles.
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