Cystic Fibrosis Airway Cells include lung fibroblasts, bronchial epithelial and bronchial smooth muscle cells. Lung fibroblasts are isolated from adult lung tissue, bronchial epithelial cells are isolated from epithelial lining of airways above bifurcation of the lungs, bronchial smooth muscle cells are isolated from the major bronchia.
Cystic fibrosis is a disease that causes thick, sticky mucus to build up in the lungs, digestive tract, and other areas of the body. It is one of the most common chronic lung diseases in children and young adults. The disease is the most common, deadly, inherited disorder affecting Caucasians in the United States. The disease eventually worsens to the point where the person is disabled. Today, the average life span for people with CF who live to adulthood is approximately 37 years, a dramatic increase over the last three decades.
Gene expression pathways
Phenotypic changes to compounds
Transfect diseased cells
Airway remodeling studies
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