Asthmatic Airway Cells include lung fibroblasts, bronchial epithelial and bronchial smooth muscle cells. Lung fibroblasts are isolated from adult lung tissue, bronchial epithelial cells are isolated from epithelial lining of airways above bifurcation of the lungs, bronchial smooth muscle cells are isolated from the major bronchia.
Asthma is an inflammatory disorder of the airways, which causes attacks of wheezing, shortness of breath, chest tightness, and coughing in patients. Degrees of severity are unique to individual patients as are responses to drug treatments. Adhesion of eosinophils to bronchial epithelial cells, and the interaction of airway smooth muscle and sub-epithelial fibroblasts play a critical role in asthma pathology. During an asthma attack bronchiole smooth muscle tissue can constrict and decrease the flow of air in the airways. The amount of air flow can further be decreased by inflammation or excess mucus secretion.
Gene expression pathways
Phenotypic changes to compounds
Transfect diseased cells
Co-culture with immune cells
Airway remodeling studies
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