ActoFactor™ Recombinant Human Trefoil factor 2

CSC-CTK0422

The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF2 has been shown to inhibit gastrointestinal motility and gastric acid secretion. Recent data suggests a potential role for TFF2 in acute and chronic asthma (Nikolaidis, N.M. et al. Am. Journal Respir. Cell Mol. Biol. (2003) 4: 458-464). Recombinant human TFF2 is a 12.0 kDa polypeptide of 106 amino acid residues, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.

Human

Human TFF2 expressed in E.coli

12.0 kDa

CAT# CSC-CTK0422-20 (20 μg); CAT# CSC-CTK0422-100 (100 μg)

E.coli

Greater than 98% as determined by HPLC and SDS-PAGE analysis.

Determined by its ability to chemoattract human monocytes using a concentration range of 1.0- 10.0 μg/ml.

Less than 1 EU/μg.

Lyophilized

Please centrifuge product briefly before opening vial. The lyophilized protein should be reconstituted in sterile, ultra-pure water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at -20°C for future use.

The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted protein should be used immediately or stored long-term in undiluted working aliquots at -20°C. Avoid repeated freeze-thaw cycles.

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