ActoFactor™ Recombinant Human Interleukin 23

CSC-CTK0270

: IL-23 is a proinflammatory heterodimeric protein composed of two subunits, a unique p19 subunit and a p40 subunit, which is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages, and signals though a receptor comprised of IL-23R complexed with IL- 12Rβ2. IL-23 has been shown to enhance proliferation of memory T cells. It also stimulates the production of IFN-γ in NK cells, induces IL-17 production, and drives Th17 mediated responses. Recombinant IL-23 is a 53.5 kDa heterodimeric protein consisting of two subunits, p19 (170 amino acids) and p40 (306 amino acids).

Human

Human IL23A expressed in E.coli

53.5 kDa

CAT# CSC-CTK0270-10 (10 μg); CAT# CSC-CTK0270-50 (50 μg)

E.coli

Greater than 95% as determined by SDS-PAGE and HPLC.

Measured by its ability to induce IL-17 secretion by mouse splenocytes.

Less than 1 EU/μg.

Sterile-filtered through a 0.2 micron filter and lyophilized from 1 x PBS (pH 7.2).

Please centrifuge product briefly before opening vial. The lyophilized protein should be reconstituted in sterile, ultra-pure water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at -20°C for future use.

The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored dessicated at -20°C. Reconstituted protein should be used immediately or stored long-term in undiluted working aliquots at –20°C. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze / thaw cycles.

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