TNF-related apoptosis-inducing ligand (TRAIL) is a ligand molecule which induces apoptosis. It is a type II transmembrane protein with homology to other members of the tumor necrosis factor family. In humans, the gene that encodes for TRAIL is located at chromosome 3q26. TRAIL binds to the death receptors, DR4 and DR5. The process of apoptosis is Caspase-8-dependent. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. Human recombinant soluble TRAIL produced in E. coli is a single, non-glycosylated polypeptide chain containing 169 amino acids (114-281) and having a molecular mass of 19.6 kDa.
Human TNFSF10 expressed in E.coli
CAT# CSC-CTK0255-50 (50 μg); CAT# CSC-CTK0255-250 (250 μg)
Greater than 95% as determined by SDS-PAGE analysis.
Sterile-filtered, colorless clear solution in 20 mM Tris (pH 7.5), 300 mM NaCl, 0.1 mM DTT & 10% glycerol.
Please centrifuge product briefly before opening vial. The dissolved protein can be diluted into other aqueous buffers and stored at -20°C for future use.
Storage & Stability
Store frozen at -20°C for longer periods of time. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
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