ActoFactor™ Recombinant Human Interferon, lambda 1 (E. coli)

CSC-CTK0192

IFN lambda-1,-2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and Interferons. All three IFN-lambdas use a distinct receptor system composed of an IFN-lambdaR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defense similar but distinct than the type I Interferons. (Kotenko, SV. et al. Nat Immunology 2003 [1] p. 69-77). Recombinant human IFN-lambda 1 is a 19.8 kDa protein containing 178 amino acid residues.

Human

Human IFNL1 expressed in E.coli

19.8 kDa

CAT# CSC-CTK0192-20 (20 μg); CAT# CSC-CTK0192-100 (100 μg)

E.coli

Greater than 98% as determined by SDS-PAGE and HPLC analysis.

Recombinant human IFN-lambda 1 induces phosphorylation of STAT2.

Less than 1 EU/μg.

Lyophilized from a sterile-filtered solution in 1x PBS with no additives.

Please centrifuge product briefly before opening vial. The lyophilized protein should be reconstituted in sterile, ultra-pure water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at -20°C for future use.

The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted rHu IFN-lambda 1 should be used immediately or stored long- term in undiluted working aliquots at -20°C. Avoid repeated freeze-thaw cycles.

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