Immortalized Human Hair Follicle Dermal Papilla Cells-hTERT

Immortalized Human Hair Follicle Dermal Papilla Cells (HFDPCs), established via the stable overexpression of Human Telomerase Reverse Transcriptase (hTERT), represent a premier in vitro model for trichology and regenerative medicine. Dermal papilla (DP) cells are the signaling center of the hair follicle, orchestrating hair growth, cycling, and regeneration. However, primary DP cells notoriously lose their inductive potential and enter senescence within a few passages. Our hTERT-immortalized line effectively solves this "phenotypic drift", providing a stable, long-term solution for hair-related research.

• Preserved Inductive Signaling: Unlike SV40T-mediated immortalization, which can significantly alter cell cycle checkpoints, hTERT immortalization maintains the cells in a more physiologically "youthful" state. These cells retain critical signaling signatures, including the Wnt/β-catenin pathway and the expression of specialized markers like Versican and Alkaline Phosphatase (ALP).
• Indefinite Expansion with Genetic Stability: By maintaining telomere length, the hTERT-HFDPCs offer an inexhaustible cell supply. This ensures high-level genetic stability and experimental reproducibility across extended passages, which is unattainable with primary cultures.
• High-Fidelity Screening Platform: The line is optimized for high-throughput screening (HTS) of hair growth promoters, anti-alopecia compounds, and cosmetic ingredients. Its consistent growth kinetics and standardized response make it a superior tool for evaluating androgenetic alopecia (AGA) mechanisms and TGF-β mediated inhibitory signaling.
• Versatility in Co-culture & Organoids: These cells are ideal for 3D "hair-on-a-chip" models or co-culture with follicular keratinocytes, allowing for the accurate reconstruction of the hair follicle's mesenchymal-epithelial interactions.

Designed to bridge the gap between unstable primary DP cells and in vivo clinical outcomes, the Immortalized Human HFDPC-hTERT line is a high-performance asset for pharmaceutical and cosmeceutical R&D. By providing a reliable, standardized human cell system, this product significantly accelerates the validation of novel hair regrowth therapeutics and diagnostic tools.