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Immortalized Human Ascending Aorta Vascular Smooth Muscle Cells
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Cat.No.
CSC-I9328L
Description
Vascular Smooth Muscle Cells (VSMCs) can perform contractile as well as synthetic functions which are associated with changes in morphology, proliferation rates, and the expression of different marker proteins such as TGFβ. Immortalized Human Ascending Aorta Vascular Smooth Muscle Cells are isolated from a male patient with bicuspid aortic valve (BAV). The phenotype varies from quiescent and contractile to proliferative and synthetic which can perform an array of functions depending on the phenotype. The immortalized cells are valuable for research studies of the expression and regulation of genes particularlyendoglin.Endoglinis downregulated in the Immortalized Human Ascending Aorta Vascular Smooth Muscle Cells in response to treatment with the drug Losartan (Cozaar) in various concentrations.
Species
Homo sapiens
Source
Heart
Culture Properties
Adherent
Morphology
Polygonal (varies depending on phenotype)
Immortalization Method
Transfection with mammalian expression vector carrying the large T SV40 antigen
Applications
For Research Use Only
Storage
Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture needed for experiments.
Note: Never can cells be kept at -20 °C.
Note: Never can cells be kept at -20 °C.
Shipping
Dry Ice.
Recommended Products
CIK-HT013 HT® Lenti-hTERT Immortalization Kit
CIK-HT003 HT® Lenti-SV40T Immortalization Kit
CIK-HT003 HT® Lenti-SV40T Immortalization Kit
Quality Control
1) Spectral karyotyping (SKY) used for chromosome analysis
2) Immunofluorescence used to determine presence of large T SV40 antigen
3) Flow cytometry used for characterization.
2) Immunofluorescence used to determine presence of large T SV40 antigen
3) Flow cytometry used for characterization.
BioSafety Level
II
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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