HT-1197

Cat.No.: CSC-C9438L

Species: Homo sapiens (Human)

Source: Bladder

Culture Properties: monolayer

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Cat.No.

CSC-C9438L

Description

Species: human - male, 44 years old, Caucasian
Tumorigenecity: yes, in mice and hamsters
Isoenzyme: G6PD, B
Production: fibrinolytic activity
Histopathology: carcinoma
Note: the cells will grow in soft agar

Species

Homo sapiens (Human)

Source

Bladder

Recommended Medium

EMEM

Culture Properties

monolayer

STR DNA Profile

D3S1358: 15,18
vWA: 16,18
FGA: 20,23
Amelogenin: X,Y
TH01: 6,9.3
TPOX: 11,12
CSF1P0: 11,12
D5S818: 12
D13S317: 11,12
D7S820: 11,12

Disease

Recurrent Bladder Carcinoma

Quality Control

Tests for mycoplasma, bacteria and fungi were negative

Storage and Shipping

Frozen with 52.5% RPMI-1640, 40% FBS, 7.5% DMSO at about 4-5 x 10^6 cells/ampoule; ship in dry ice; store in liquid nitrogen

Synonyms

HT 1197; HT1197; HT 1197.T

Citation Guidance

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.

HT-1197 is a bladder carcinoma cell line derived from human bladder carcinoma. It was derived from a high-grade transitional cell carcinoma of urinary bladder of unknown primary tumor origin. These cells exhibit features of an invasive phenotype commonly seen in urothelial cancers and serve as an in vitro bladder cancer model to study tumor progression and response to therapies.

HT-1197 cells are epithelial-like adherent cells that form monolayers. Morphologically, these cells are polygonal to cobblestone, typical of bladder cancer cells. HT-1197 cells have been shown to proliferate rapidly and can be maintained with normal growth rates. Karyotyping and gene expression studies have shown HT-1197 cells to have chromosomal abnormalities and dysregulated expression of genes involved in important cellular pathways.

HT-1197 cells have been used as models to study bladder cancer cell invasion and metastasis. Studies focus on regulation of cell-cell and cell-matrix adhesion, migration, and expression of molecules involved in these pathways. These cells have also been used to study the therapeutic response of urothelial carcinoma cells to chemotherapeutic drugs, targeted therapeutics and drug combinations.

Pulsed Electromagnetic Field Therapy Alters the Genomic Profile of Bladder Cancer Cell Line HT-1197

Pulsed electromagnetic field (PEMF) therapy uses magnetic waveform energy for targeted treatment and has shown promise in various cancers. Given the invasive nature of current bladder cancer treatments, Sandberg et al. investigated PEMF's effects on bladder cancer cells in vitro.

In HT-1197 cells, PEMF treatment significantly reduced proliferation compared to controls (growth rate: 0.0152 vs. 0.0176; p < 0.05, CI 4.8-27.5; R² = 0.99 for both; Fig. 1 and Fig. 2a). In contrast, HT-1376 cells showed no significant growth difference (p = 0.353, CI -108.7-39.4; R² = 0.96 and 0.94; Fig. 2b). Principal component analysis revealed complete separation between PEMF-treated and control HT-1197 cells, with PC1 accounting for 76% of variation (Fig. 3a). Transcriptome analysis identified 49 differentially expressed transcripts, visualized by heatmap showing distinct up- and downregulation patterns in PEMF-treated cells (Fig. 3b).

HT-1197 cells in culture. — Fig. 1. HT-1197 cells in culture (Sandberg M, Whitman W, *et al.*, 2025).

Cell growth curves. Representation of the exponential growth curves of both the control (blue) and PEMF-treated cells (orange). — Fig. 2. Cell growth curves. Representation of the exponential growth curves of both the control (blue) and PEMF-treated cells (orange) (Sandberg M, Whitman W, *et al.*, 2025).

Principal component analysis and hierarchical clustering. — Fig. 3. Principal component analysis and hierarchical clustering (Sandberg M, Whitman W, *et al.*, 2025).

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For research use only. Not for any other purpose.