COR-L23/R

Cat.No.: CSC-C9495J

Species: Homo sapiens (Human)

Source: Liver Metastasis

Morphology: Epithelial

Culture Properties: Adherent

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Cat.No.

CSC-C9495J

Description

The cell line COR-L23/R is a multi-drug resistant (MDR) sub-line derived from the parent line COR-L23 after treatment with doxorubicin (adriamycin). The P-glycoprotein negative cell line is cross resistant to daunorubicin, vincristine and rhodamine 123. Drug resistance is caused by enhanced drug efflux that can be inhibited by addition of buthionine sulphoximide (BSO), an inhibitor of glutathione synthesis. COR-L23/R contain reduced levels of glutathione and glutathione-S-transferase activity compared to the parent line. MDR seems to be connected with overexpression of multi-drug resistance-associated protein (MRP) which is discussed as a drug transporter.

Species

Homo sapiens (Human)

Source

Liver Metastasis

Recommended Medium

RPMI 1640 + 2mM Glutamine + 0.2μg/ml Doxorubicin + 10% Fetal Bovine Serum (FBS) Start without drug. Add drug after first passage and then add at all subsequent passages.

Culture Properties

Adherent

Morphology

Epithelial

Disease

Gastric Tubular Adenocarcinoma

Storage and Shipping

Creative Bioarray ships frozen cells on dry ice. On receipt, immediately transfer frozen cells to liquid nitrogen (-180 °C) until ready for experimental use.
Never can cryopreserved cells be kept at -20 °C.

Citation Guidance

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.

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For research use only. Not for any other purpose.