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COR-L23/R
- Specification
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Cat.No.
CSC-C9495J
Description
The cell line COR-L23/R is a multi-drug resistant (MDR) sub-line derived from the parent line COR-L23 after treatment with doxorubicin (adriamycin). The P-glycoprotein negative cell line is cross resistant to daunorubicin, vincristine and rhodamine 123. Drug resistance is caused by enhanced drug efflux that can be inhibited by addition of buthionine sulphoximide (BSO), an inhibitor of glutathione synthesis. COR-L23/R contain reduced levels of glutathione and glutathione-S-transferase activity compared to the parent line. MDR seems to be connected with overexpression of multi-drug resistance-associated protein (MRP) which is discussed as a drug transporter.
Species
Human
Source
Lung
Recommended Medium
RPMI 1640 + 2mM Glutamine + 0.2µg/ml Doxorubicin + 10% Foetal Bovine Serum (FBS). Start without drug. Add drug after first passage and then add at all subsequent passages.
Culture Properties
Adherent
Morphology
Epithelial
Storage and Shipping
Creative Bioarray ships frozen cells on dry ice. On receipt, immediately transfer frozen cells to liquid nitrogen (-180 °C) until ready for experimental use.
Never can cryopreserved cells be kept at -20 °C.
Never can cryopreserved cells be kept at -20 °C.
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
- Q & A
- Customer Review
Q:
What is ATP assay for cell viability?
A:
ATP assays are procedures that can measure cell viability based on the detection of ATP. Higher ATP concentration indicates a higher number of living cells.
Average Rating: 5.0 | 1 Scientist has reviewed this product
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I am impressed with the wide range of tumor cell lines offered by Creative Bioarray. Their diverse selection allowed me to find the perfect cell line for my research needs.
04 Feb 2023
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