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COR-L23/R

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Cat.No.
CSC-C9495J
Description
The cell line COR-L23/R is a multi-drug resistant (MDR) sub-line derived from the parent line COR-L23 after treatment with doxorubicin (adriamycin). The P-glycoprotein negative cell line is cross resistant to daunorubicin, vincristine and rhodamine 123. Drug resistance is caused by enhanced drug efflux that can be inhibited by addition of buthionine sulphoximide (BSO), an inhibitor of glutathione synthesis. COR-L23/R contain reduced levels of glutathione and glutathione-S-transferase activity compared to the parent line. MDR seems to be connected with overexpression of multi-drug resistance-associated protein (MRP) which is discussed as a drug transporter.
Tissue of Origin
Lung
Organism
Human
Culture Properties
Adherent
Morphology
Epithelial
Recommended Medium
RPMI 1640 + 2mM Glutamine + 0.2µg/ml Doxorubicin + 10% Foetal Bovine Serum (FBS). Start without drug. Add drug after first passage and then add at all subsequent passages.
Storage
Creative Bioarray ships frozen cells on dry ice. On receipt, immediately transfer frozen cells to liquid nitrogen (-180 °C) until ready for experimental use.
Never can cryopreserved cells be kept at -20 °C.
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the Pub Med ID of your paper to get a coupon.
CSC-6252W
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CSC-6276W
CSC-6302W
CSC-6303W
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