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Immortalized Rat Odontoblast Cells
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Cat.No.
CSC-I9246L
Description
Odontoblasts are useful in studying the development of mineralized tissue, such as dentin. They are especially useful if performing experiments relating to characterization of odontoblast-specific genes in dentinogenesis. The Immortalized Rat Odontoblast Cells retain the expression of proteins involved in dentinogenesis, namely the dentin matrix proteins DMP1, DMP2, and DMP3, which are needed for development of mineralized dentin. Other proteins which are expressed by this cell line are the extracellular matrix proteins alkaline phosphatise (ALP), CBFA1, collagen type 1 (COL1), and amenoblastin (AMBN). This cell line is also capable of mineralization inin vitroandin vivosettings, making them ideal for studying dentin formation, genes implicated in odontoblast development and differentiation, as well as tissue engineering to make reparative dentin.
Source
Molar tooth germs
Culture Properties
Adherent
Immortalization Method
Human telomerase reverse transcriptase (pCI-Neo-hTERT)
Markers
DMP1, DMP2, DMP3
Applications
For Research Use Only
Storage
Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture needed for experiments.
Note: Never can cells be kept at -20 °C.
Note: Never can cells be kept at -20 °C.
Shipping
Dry Ice.
Recommended Products
CIK-HT003 HT® Lenti-SV40T Immortalization Kit
Quality Control
1) Expression of DMP1, DMP2, and DMP3 detected by RT-PCR and immunostaining;
2) in vitro mineralization activity confirmed by Von Kossa staining;
3) in vivo mineralization activity verified bysubcutaneous and intramuscular implantation.
2) in vitro mineralization activity confirmed by Von Kossa staining;
3) in vivo mineralization activity verified bysubcutaneous and intramuscular implantation.
BioSafety Level
II
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
CSC-I9001L
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