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Immortalized Rat Metanephric Mesenchymal Precursor Cells (KMM)
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Cat.No.
CSC-I9241L
Description
Kaposi’s sarcoma-associated herpesvirus (KSHV) has been linked to several malignancies in AIDS patients, but the mechanisms involved are unknown. Past studies has postulated that KSHV targets precursor cells. Metanephric mesenchymal precursors are cells that are able to differentiate into different lineage of cells, including interstitial stroma, mesangial, vascular smooth muscle, cap mesenchyme, and loose mesenchyme cells.The Immortalized Rat Metanephric Mesenchymal Precursor Cells (KMM) is suitable for KSHV infection related studies, such as the growth deregulation mechanisms, as it is able to cause tumor formation. The cells have been efficiently transformed and are immortalized by KSHV. It expresses vascular endothelial, lymphatic endothelial, mesenchymal, and hemapoietic precursor markers. There is downregulation of Thy1.1 expression, a tumor suppressor. These cells are recommended for research on cancer formation linked to KSHV.
Source
Kidney
Culture Properties
Adherent
Morphology
Spindle-shaped
Immortalization Method
Serial passaging and infection by Kaposi’s sarcoma-associated herpesvirus (KSHV)
Markers
β-catenin, vWF, VEGFR-1, VEGFR-3, LYVE-1, vimentin, CD34, VCAM-1, ICAM-1, CD31
Applications
For Research Use Only
Storage
Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture needed for experiments.
Note: Never can cells be kept at -20 °C.
Note: Never can cells be kept at -20 °C.
Shipping
Dry Ice.
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Quality Control
Immunofluorescence assay, Western blot, and immunohistochemistry was preformed to detect cell markers
BioSafety Level
II
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
CSC-I9001L
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