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Immortalized Mouse Cementoblasts
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Cat.No.
CSC-I9216L
Description
The cementum is a mineralized tissue lining the tooth root surface and shares many properties with mineralized tissues such as the bone. It has a role in reparative activities, the regeneration of tissues, and is responsible in maintaining healthy periodontium. The Immortalized Mouse Cementoblasts is immortalized with mouse SV40 large T antigen, and retains phenotypic characteristics of the primary cells such as the expression of parathyroid hormone 1 receptor (PTH-1), noncollagenous proteins (BSP, OC, OPN), and type I collagen. Furthermore, this cell line has been shown to respond to the presence of the parathyroid hormone (PTH) and the parathyroid hormone-related protein (PTHrP), and is able to stimulate mineral nodule formation, which makes it a useful tool to study the mechanisms involved in regulating the molecular biological activity and properties of the cementum or mineralized tissues, biomineralization, and affects of the PTH-1 receptor.
Species
Mus musculus, CD-1 Mouse
Source
Mandibular First Molars
Culture Properties
Adherent
Morphology
Polygonal
Immortalization Method
Serial passaging and transduction with recombinant lentiviruses carrying SV40 Large T antigen
Markers
Bone sialoprotein (BSP), Osteocalcin (OC), Osteopontin (OPN), Type I collagen
Applications
For Research Use Only
Storage
Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture needed for experiments.
Note: Never can cells be kept at -20 °C.
Note: Never can cells be kept at -20 °C.
Shipping
Dry Ice.
Recommended Products
CIK-HT003 HT® Lenti-SV40T Immortalization Kit
Quality Control
Expression of PTH-1 was assessed by Northern blot and gene-expression assay. Markers were analyzed by RT-PCR.
BioSafety Level
II
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
CSC-I9001L
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