SuperQuick® Cytochrome P450 1A2 (CYP1A2) Activity Assay Kit

DMK-YS009

CYP1A2 catalyzes the oxidation of polyaromatic hydrocarbons and heterocyclic compounds and is found mostly in the liver, nasal mucosal tissues, and the intestine. About 10% of routinely used small molecule medicines have CYP1A2 implicated in their metabolism. Clinical drug-drug interactions involving frequently used medications, such as caffeine, theophylline, and the antipsychotic clozapine, have been linked to polymorphisms in the human CYP1A2 gene. Environmental carcinogens included in cigarette smoke and combustion exhaust are also activated metabolically by isoforms of the CYP1A2 subfamily.Creative Bioarray's CYP1A2 Activity Assay Kit enables rapid measurement of native or recombinant CYP1A2 activity in biological samples, such as liver microsomes.

Rapid assessment of native/recombinant CYP1A2 activity in fractions prepared from tissues and cells.
Screening compounds for interaction with native/recombinant CYP1A2.

Simple and ready to use;
With little interference by autofluorescence.
Rapid and hight sensitive.

Liver microsomes and liver S9 fractions;
Tissue and cultured cell lysates, primary hepatocytes;
Heterologous expression of recombinant CYP1A2 preparations.

CYP1A2Assay Buffer;
3-CHC Standard ;
CYP1A2 Inhibitor (α-naphthoflavone);
NADPH Generating System(100X);
β-NADP+Stock (100X);
CYP1A2 Substrate;
Recombinant Human CYP1A2.

100 assys

Strore at -20℃.

Gel Pack

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.

DMK-YS001

DMK-YS002

DMK-YS003

DMK-YS004

DMK-YS005

DMK-YS006