HS-SY-II
Cat.No.: CSC-C6322J
Species: Homo sapiens (Human)
Source: Pleural Effusion Metastasis
Morphology: other
Culture Properties: Adherent cells
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Store in liquid nitrogen.
The HS-SY-II cell line is a well-characterized human cell line derived from a metastatic lesion (pleural effusion) of a myxoid liposarcoma (MLS), a distinct subtype of soft tissue sarcoma. MLS is clinically and genetically unique, defined in approximately 90-95% of cases by a pathognomonic chromosomal translocation, t(12;16)(q13;p11), which generates the FUS-DDIT3 (also known as CHOP) fusion oncogene. This chimeric protein acts as an aberrant transcription factor, driving adipocytic differentiation arrest and tumorigenesis. The HS-SY-II line is confirmed to harbor this characteristic FUS-DDIT3 fusion, making it a genetically faithful in vitro and in vivo model for this specific sarcoma subtype, which is particularly sensitive to radiotherapy but prone to late metastases.
Key characteristics of HS-SY-II cells include an adherent, spindle-shaped to round morphology reflective of its mesenchymal origin. Critically, they maintain expression of the fusion oncoprotein and demonstrate a gene expression profile consistent with MLS. The line is tumorigenic in immunocompromised mice, forming xenografts that recapitulate aspects of the human tumor histology, a vital feature for translational pre-clinical studies.
Anti-Tumor Effect of Plasma-Activated Medium on Synovial Sarcoma Cell Line HS-SY-II
This study aimed to investigate the anti-tumor effects of plasma-activated medium (PAM) on synovial sarcoma and its underlying mechanisms, focusing on the quantitative analyses of both intracellular reactive oxygen species (ROS) and cell apoptosis.
The human synovial sarcoma cell line HS-SY-II was used to investigate the cell viability after PAM treatment. Moreover, we observed PAM-induced intracellular ROS accumulation and cell apoptosis and assessed the involvement of intracellular ROS in the anti-tumor effects of PAM using an intracellular ROS scavenger.
PAM significantly decreased the viability of synovial sarcoma cells compared with untreated Dulbecco's modified Eagle medium. Regarding anti-tumor mechanisms, PAM induced significant cell apoptosis and intracellular ROS accumulation. The intracellular ROS scavenger significantly inhibited the anti-tumor effect of PAM.
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