In B-ALL, CD19 has been involved in antigen escape after anti-CD19 CAR-T therapy. Thus, the development of CAR-T cells targeting other pan-B cell markers, such as CD20 and CD22, are thought to be ideal targets for dual or tandem CAR-T therapy. The Anti-CD22 CAR-T Cell ISH Probe targeting the CAR 3’ UTR allows for highly sensitive and especific detection of Anti-CD22 CAR-T cells.
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