TOP2A/Her2/CEP 17 Triple-Color Probe

FONC-116

The TOP2A gene, located at 17q21-q22 encodes topoisomerase II-α, a key enzyme in DNA replication, cell cycle progression, and chromosome segregation. As a key enzyme in DNA replication, TOP2A protein is the molecular target for many inhibitors. The TOP2A gene is located telomeric to the HER-2 oncogene, which is located in the 17q11.2-q12 region. HER-2 is one member of a family of transmembrane protein receptors. The close proximity of HER-2, TOP2A, and other genes in the 17q region, suggest a potential relationship between these genes. The TOP2A gene has also been shown to be co-amplified with HER-2 in cell lines and in human breast cancers. TOP2A and HER-2 gene status is of interest since topoisomerase II-α is a molecular target of anthracycline drugs and HER-2 is targeted by several small molecule tyrosine kinase inhibitors as well as antibodies against the HER-2 receptor protein. Beser et al used the TOP2A/HER-2/CEP17 FISH Probe Kit to examine the frequency of TOP2A amplification and deletion relative to the HER-2 gene status and chromosome 17 aneusomy in a series of 50 breast tumors. Hicks et al used the same probe set to similarly document the relationship between TOP2A and HER-2 genomic alterations and chromosome 17 aneusomy in 138 breast cancers

10 Tests, 200 Tests

Red/Green/Blue

Human

17q21/17q12/SE 17

For Research Use Only. Not for use in diagnostic procedures.

Store at minus 20 centigrade

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.